Ventajas
Expedia is far and away the most supportive of a work/life balance out of all of my friends' employers. When I have been upset, my managers have gone to bat for me. When I need to say something to upper management or people in distant organizations, I am empowered to do so. When I have wanted time off, I have been granted it. When I have asked for projects fitting certain criteria, I have been given them. When I have considered leaving, or been given offers elsewhere, my managers have asked me to stay and have worked with me to ensure my happiness. We work in a space that is interesting and relevant to me, in a company that isn't as huge as MS, Yahoo, Google, etc, but is not victim to the risks or lack of resources that a startup experiences.
Desventajas
All companies have issues. It seems like there are some vocal people who are disaffected with the spirit, pay, freedom, and support in the company, but I suspect they won't find much better elsewhere. Personally, I find the commute to the new space in downtown Bellevue unappealing, I know the benefits at Microsoft are much better, and the constantly rotating senior management is pretty irritating.